M2
The cochlea — the peripheral sensory organ for hearing — encodes sound into action potentials, which are then transmitted via the auditory nerve to the auditory brain for sound processing and analysis. Biophysically realistic computational models of the cochlea and auditory nerve have been developed over several decades and are now well established. Unlike artificial neural networks, these models are grounded in biological realism, replicating the actual stages of sound processing and offering valuable insights into both normal auditory function and its dysfunctions. For example, they can simulate various types of hearing loss caused by acoustic overexposure, aging, or genetic disorders.
However, the use of these models has remained limited for two main reasons:
i) Very few models simulate the auditory brainstem nuclei beyond the auditory nerve, which are more complex due to the diversity of cell types and poorly understood anatomical connections;
ii) Existing models do not reproduce field potentials — such as electroencephalograms (EEG) — which are recorded via scalp electrodes in humans or subcutaneous electrodes in animals, and which serve as critical biomarkers in diagnosing auditory disorders.
The goal of this internship is threefold:
i) To implement state-of-the-art computational models that include upper components of the auditory system, such as the inferior colliculus in the midbrain;
ii) To simulate field potentials based on the activity of individual neurons generated by these models;
iii) To reproduce the altered field potentials observed in two mouse models developed by the team — one with auditory neuropathy and another in which deafness has been cured — both characterized by impaired auditory nerve responses.
Proficiency in programming (Matlab/Python) and signal processing is required. A strong interest in biology and sensory systems is also important.
This work would take place at the brand-new Institut de l’Audition, a center from Institut Pasteur, located 63 rue de Charenton, 75012 Paris, and could start in mid-January/February 2026
Please provide a CV and a motivation letter to:
Boris Gourévitch : boris@pi314.net
Nicolas Michalski : nicolas.michalski@pasteur.fr